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This indicated the requirement for designing adaptive management scenarios. Hence, the extended SWAT model could be a powerful tool for future regional to global scale modelling of nutrient loads and effective surface and groundwater management.As the main theory of carcinogenesis, the Somatic Mutation Theory, increasingly presents difficulties to explain some experimental observations, different theories are being proposed. A major alternative approach is the Tissue Organization Field Theory, which explains cancer origin as a tissue regu
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