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The study's aim was to identify and validate phenotypes of patients with musculoskeletal (MSK) pain based on eleven common prognostic factors across the biopsychosocial domains. Using a sample of n=435 patients attending physiotherapy in primary care, latent class analysis identified five groups. The five groups mainly differed in terms of severity across the well-established prognostic factors. Outcomes at 3 months reflected baseline scores; those with a more severe profile had worse clinical outcomes. Two of the five groups were separate