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The present research aimed to assess the end result of non-surgical periodontal treatment on gingival crevicular substance (GCF) HIF-1α, VEGF and TNF-α levels in general aggressive periodontitis (G-AgP). TECHNIQUES 20 G-AgP patients and 20 periodontally healthy people had been included. G-AgP patients got scaling and root planning (SRP), per quadrant at a 1-week-interval, performed with ultrasonic and periodontal hand devices. GCF samples had been col