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These results demonstrated great differences of the subcellular localization and accumulation capacity of Mn between oocytes and sperm cells in oysters, implying the sex differentiation in susceptibility of reproductive response to Mn stress. Our study also highlights the importance of gender difference in future biomonitoring and ecotoxicological studies of Mn in marine bivalves.Type-2-diabetes is considered the new plague of the current century and its incidence and prevalence are rapidly increasing. Chronic insulin resistance and a pro
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