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In the phantom study, we reached 100 and 94.7% monitoring reliability in 3 cm and 2 cm spherical masses, respectively. This needed 32.5 ms/frame (30.8 fps) real-time handling. CONCLUSIONS We proved the possibility feasibility of a real-time markerless tumour monitoring framework for stereotactic lung radiotherapy considering patient-specific DL with personalised data generation with electronic phantom and epoxy phantom studies. ADVANCES IN KNOWLEDGE making use of DL with personalised da