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Addition of 20 mM or 5 mM amino acids to 100 mg/L Ni (II)-treated strain D2 restored its growth. This study provides insights into the way to alleviate the Ni (II) toxicity in strain D2, thus contributing to the development of bioremediation strategies.Despite numerous studies on effects of environmental accumulation of nano-pollutants, the influence of nanoparticles on the biological perturbations of coexisting pollutants in the environment remained unknown. The present study aimed at elucidating the perturbations of six environmental