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The KM curves of pathologic N0 and N1 showed that low-risk group were associated with a better overall survival (p= 1.518e; p= 1.704e-01). The pathways related to risk grouping were cytokine-cytokine receptor interaction, JAK stat signaling pathway, and glycolysis-gluconeogenesis. On the basis of this study, we established a prognostic risk model, which provided a reliable prognostic tool and was of great significance for locating the biomarkers related to survival prognosis in CSCC. On the basis of this study, we established a prognostic