https://www.selleckchem.com/pr....oducts/gi254023x.htm
A novel, nonsurgical approach to interrupting the enterohepatic circulation is inhibition of the ileal bile acid transporter, a key molecule in the enterohepatic circulation that reabsorbs bile acids from the intestine. Ileal bile acid transport inhibition has been shown to reduce serum bile acids and pruritus in trials of pediatric cholestatic liver diseases. This review explores the rationale of inhibition of the ileal bile acid transporter as a therapeutic target, describes ileal bile acid transport inhibitors in development, and s
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