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In this matter of Neuron, Ashrafi et al. (202 recognize a feedforward signaling system that couples neuronal task to the homeostatic upkeep of axonal and synaptic ATP manufacturing. This method is accomplished via alterations in cytoplasmic calcium and activation of brain-specific, mitochondrial MICU3. Balance between excitation and inhibition (E-I balance) in neural circuits is believed is securely controlled. To your contrary, in this matter of Neuron, Bridi et al. (202 reveal that in
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