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This preferential internalization is expected to have strong impact on cardiac repolarization. Our results suggest that KCNE1(S102) is an important anti-arrhythmic drug target to prevent IKs pathological remodeling leading to cardiac arrhythmias.Satellite-based methods are proposed for the estimation of clear day average hourly illuminance from satellite data under local climate conditions. First, aerosol optical depth (AOD) data collected using a ground-based sun photometer were used to calibrate the satellite remote sensing AOD data.