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WIN55,212-2 had a similar pattern as 2-arachidonylglycerol (reference). The other agonists displayed bias towards internalisation compared to cAMP inhibition. However, only Δ9 -tetrahydrocannabinol and BAY59,3074 demonstrated bias in the pERK-cAMP pathway comparison. Furthermore, all the agonists exhibited little preference between internalisation and pERK. CONCLUSION AND IMPLICATIONS This is the first joint kinetic assessment of biased agonism at a GPCR (e.g., CB1 receptor) under non-equilibrium conditions. Kinetic modelling is a natural
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