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Clinical Trial Registration http//www.chictr.org/cn/proj/show.aspx?proj=1441, unique identifier ChiCTR-TNC-11001489.Background Patients with acute type A aortic dissection are usually transferred to the intensive care unit (ICU) after surgery. Prolonged ICU length of stay (ICU-LOS) is associated with higher level of care and higher mortality. We aimed to develop and validate machine learning models for predicting ICU-LOS after acute type A aortic dissection surgery. Methods A total of 353 patients with acute type A aortic dissection tr