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Compared with A101 allele, A307 allele has two missense mutations, 467C T and 745C T, which have resulted in substitutions Pro156Leu and Arg249Trp in the A glycosyltransferase polypeptide chain. CONCLUSION A variant allele (A307) has been identified for the first time in mainland China, which is responsible for the formation of A3 phenotype. To explore the molecular basis for an individual with a rare weak D phenotype. Regular serological assaying and indirect antiglobulin testing (IAT) were performed to characterize the RhD blood