https://www.selleckchem.com/pr....oducts/tat-beclin-1-
Background Thyroxine (T4) to triiodothyronine (T3) deiodination in the hypothalamus/pituitary is mediated by deiodinase type-2 (D2) activity. Dio2(-/-) mice show central resistance to exogenous T4. Patients with Resistance to Exogenous Thyroxine (RETH) have not been described. Aim To identify hypothyroid patients with TSH unresponsiveness to levothyroxine (L-T4) and to characterize the clinical, hormonal and genetic features of human RETH. Methods We investigated hypothyroid patients with elevated TSH under L-T4 treatment
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