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The incidence of sepsis increased 2.7 times between 2008 and 2017, achieving a hospital occurrence of 5.7 every 10,000 inhabitants in 2017. Case fatality rate (CFR) had been 23.2% and 35.0% in patients without in accordance with organ dysfunction in 2017, respectively, and 42.9% in patient with septic surprise, lowering over time. Mean annual direct medical expenses of specialised treatment within the research duration were €6664 and €80