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In isolated guinea pig hearts AP30663 dramatically extended the atrial efficient refractory period (AERP) with small effects in the QT-interval corrected for heartrate. Likewise, in anaesthetized rats 5 and 10 mg/kg of AP30663 changed the AERP to 130.7±5.4% and 189.9±18.6 of baseline values. The expression quantitative trait loci analyses unveiled that the genome wide association studies for AF SNP rs13376333 in KCNN3 is associated with add