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Furthermore, transiently overexpression of miR477-3p in tomatoes leading to a decline in their targeted disease related genes expression. Our results firstly identified circRNAs in tomato upon P. infestans infection and demonstrated that circRNA45 and circRNA47 may act as positive regulators in tomato resistance by regulating miRNA-mRNAs expression levels. Diabetic retinopathy (DR) is a frequent complication of diabetes and it can lead to visual impairment and blindness. However, the mechanism of their regulation remains little known. circ