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These structural events stabilize and lock GTP within the closed pocket for cyclization. In the cGMP-bound complex, αL2 detaches from βh2 and establishes interactions with βL2, which results in the loss of global structure compactness. Furthermore, with the release of pyrophosphate, the interaction between αh1 and βL2 weakens, abolishing the tight packing of the binding pocket. This study discusses the conformational changes induced by the binding of GTP and cGMP to the hsGC catalytic domain, valuable in designing new therapeutic strateg
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