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Suggesting that this method can significantly improve the uniformity of alloying elements in the thickness direction of the twin-roll cast slab, ultimately improve the mechanical properties of AA6022 aluminum alloy.Immunotherapy has considerably increased the number of anticancer agents in many tumor types including metastatic colorectal cancer (mCRC). Anti-PD-1 (programmed death 1) and cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) immune checkpoint inhibitors (ICI) have been shown to benefit the mCRC patients with mismatch repair