https://www.selleckchem.com/pr....oducts/crenolanib-cp
C3aR antagonists could block these effects. In Heymann nephritis rats, C3aR blockade attenuated proteinuria, electron-dense deposition, foot process width, and glomerular basement membrane thickening in glomeruli. The increased plasma C3a levels and overexpression of C3aR were also alleviated. Specific, but not total, IgG levels decreased, with less deposition of rat IgG in glomeruli and subsequent reduction of C1q, factor B, and C5b-9. C3a anaphylatoxin is a crucial effector of complement-mediated podocyte damage in MN. Th
Like
Comment
Share
