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The models are efficient since the prediction of chondrocyte dynamics is comparable to the cell growth and to the molecular synthesis observed experimentally. This novel formulation may be dynamic because the variables that fit the models may be modified to improve in vitro procedures focused on cartilage recovery. The reduced, interactive, quadratic and combined models exhibited lower R2 values, nevertheless, they were useful to predict proliferation and glycosaminoglycan synthesis, as the right-skewed distribution, determined by the