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BACKGROUND Prescription opioid overdose has increased markedly and is of great concern among injured workers receiving workers' compensation insurance. Given the association between high daily dose of prescription opioids and negative health outcomes, state workers' compensation boards have disseminated Morphine Equivalent Daily Dose (MEDD) guidelines to discourage high-dose opioid prescribing. OBJECTIVE To evaluate the impact of MEDD guidelines among workers' compensation claimants on prescribed opioid dose. METHODS Workers' compensatio