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d with increased risk of rAEs in IMID patients compared to the second vaccination. Patients with an IMID have a modestly increased risk of rAEs after vaccination when compared to controls. Most AEs are resolved within 7 days; hospital admissions and allergic reactions were uncommon. NL74974.018.20 , Trial ID NL8900. Registered on 9 September 2020. NL74974.018.20 , Trial ID NL8900. Registered on 9 September 2020. Circular RNAs (circRNAs) are differentially expressed between normal and cancerous tissues, contributing to tumor initiation and progressi