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Mesothelioma Diagnosis A doctor can determine the condition by physical examination, imaging tests and lab tests. Doctors may also perform biopsy, which entails taking tissue and then examining it under a magnifying glass. A chest X-ray or CT scan, is used to guide the needle through the lining of the lung. The procedure is not invasive and can produce false-negative results. Diagnosis Mesothelioma is a rare cancer, which means it takes a while to determine an accurate diagnosis. Your doctor will start by taking a medical history, and then do