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We aim to explore and compare the effect of global travel restrictions and public health countermeasures in response to COVID-19 outbreak. A data-driven spatio-temporal modelling to simulate the spread of COVID-19 worldwide for 150 days since 1 January 2020 under different scenarios. Worldwide. Travel restrictions and public health countermeasures. The cumulative number of COVID-19 cases. The cumulative number of COVID-19 cases could reach more than 420 million around the world without any countermeasures taken. Under timely and inten