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Pandemics of infectious diseases have long been regarded as societal challenges. This study aimed to summarize the theories of Persian medicine for controlling respiratory disease-related pandemics and to compare these theories with the findings of modern medicine. We searched the classic medical reference books of the 9th to 19th centuries for the terms 'polluted air' and 'pandemic', and we searched 4 databases (PubMed, Google Scholar, Science Direct, and Scopus) with the keywords 'COVID-19', 'pandemic', 'history', and 'prevention pro