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Tomasetti and Vogelstein's claim can partly answer comprehensively the question. They postulated that the proliferation price of regular stem cells in certain structure is higher than that of other cells, and correctly, the incidence of cancer in these tissues is large. In compliance with CSCs paradigm, resident typical stem cells of cells are the most possible way to obtain CSCs. After homing of metastatic disease cells in a tissue with a high rate of normal stem cell proliferation, discover a big chance
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