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F, P = 0.043). However, there was no difference in the extent of GATA3 Th2 or FOXP3 Treg infiltration before and after treatment in either UDCA responders or nonresponders. Collectively, our results suggest that a decrease in the number of liver-infiltrating CD4 Th1 cells is associated with a good response of PBC patients to UDCA treatment. Immunohistochemical analysis of CD4 and T-bet in PBC liver specimens may be a potential approach for evaluating the therapeutic response to UDCA. Collectively, our results suggest that a decrease in th