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e that by actively challenging niche communities, phages play crucial roles in the diversification of Antarctic communities. Copyright © 2020 Bezuidt et al.Insights into the interaction between phages and their bacterial hosts are crucial for the development of phage therapy. However, only one study has investigated global gene expression of Clostridioides (formerly Clostridium) difficile carrying prophage, and transcriptional reprogramming during lytic infection has not been studied. Here, we presented the isolation, propagation,