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Assessing the therapeutic potential of this drug combination in this platform, we revealed that the expression of PD-L1 increased in 3D co-cultures. The cost- and time-effective establishment of our 3D co-culture model and its application as a pre-clinical drug screening platform can facilitate the treatment validation and clinical translation.In this research, high strength fiber reinforced concrete (HSFRC) was used to replace the normal strength concrete (NSC) in steel-concrete composite beams to improve their working performance, whic