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However, serum LCN2 correlated with age in healthy women ( =0.44; =0.003) and men ( =0.5; =0.001) and serum concentrations of DKK1 ( =0.47; P=0.003) and urinary NTX ( =0.34; =0.04). Sobel mediation analysis showed that LCN2 mediates an indirect relationship between age and DKK1 ( =0.02), but not with NTX, in healthy subjects. Taken together, the results suggest a hitherto unknown association between LCN2, DKK1 and age in healthy individuals, but not in postmenopausal osteoporotic women. Taken together, the results suggest a hitherto u
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