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FERM stability is demonstrated by a high correlation between 19F and 89Zr content in blood (correlation coefficient 0.99). Image sensitivity is observed in an acute infection rodent model at low dose (37 kBq). The versatility of FERM is further demonstrated in inflammatory bowel disease and 4T1 tumor models. Conclusion Multimodal detection using FERM yields robust whole-body lesion detection and leverages the strengths of combined PET/19F MRI. FERM nanoemulsion production is scalable and potentially useful for precise diagnosis, s