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Nurses experience loneliness, anxiety, fear, fatigue, sleep disorders, and other physical and mental health problems due to their close contact with patients in cases of epidemic diseases. Among nurses in Turkey, we want to explore how anxiety, psychological health, and social isolation affect nurses' quality of life. This study aimed to investigate the effects of the COVID-19 pandemic on the quality of life (COVID-19 EQLS), State-Trait Anxiety Inventory (STAI-1 and STAI-2), psychological health, and social isolation among nurses. It also