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Remaley showed results from treatment of an FLD patient with rhLCAT. Dr. Karathanasis showed that rhLCAT infusion in mice stimulates cholesterol efflux and suggested that it could also enhance cholesterol efflux from macrophages. While the role of LCAT in atherosclerosis remains elusive, the consensus is that a continued study of both the enzyme and disease will lead towards better treatments for patients with heart disease and FLD.The X inactive-specific transcript (Xist) gene is the master regulator of X chromosome inactivation in mam