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Background A synapse is a fundamental signaling component that facilitates neuronal connectivity and information processing in the brain. Dynamic changes in the number, size, and functionality of synapse are induced by extensive signaling networks and structural proteins, which are stimulated on various neuronal activities. Changes in the expression level of synaptic proteins depend upon the physiological and pathological conditions at transcriptional, post-transcriptional, and post-translational levels. MicroRNAs (miRNAs) have not only em