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To identify the symptom clusters of early-stage poststroke depression (PSD) and provide an in-depth understanding of the symptoms. A mixed-methods study with a convenient sampling method was used. A cross-sectional questionnaire survey in 231 stroke patients and semi-structured interviews in 14 stroke patients were conducted in the neurological department of a comprehensive hospital in Southeast China. Data from the questionnaire survey were analysed through descriptive and exploratory factor analyses; data from the semi-structured interview we