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In in vitro model, CM increased muscle degradation factors and decreased adipocytes differentiation factors. However, these tendencies were ameliorated by AF treatment in C2C12 myoblasts and 3T3-L1 cells. Taken together, our study demonstrated that AF could be a therapeutic supplement for patients suffering from cancer cachexia. Taken together, our study demonstrated that AF could be a therapeutic supplement for patients suffering from cancer cachexia.Pulmonary arterial hypertension (PAH) is a complex multifactorial disease with both ge