https://www.selleckchem.com/products/escin.html
Using in vitro cultures of lung primary fibroblasts, we confirmed that Notch3 participates in their survival and differentiation. Thus, Notch3 deficiency mitigates the development of lung fibrosis because of its role in mediating fibroblast activation. Our findings reveal a previously unidentified mechanism underlying lung fibrogenesis and provide a potential novel therapeutic approach to target pulmonary fibrosis.Fibroblast activation is transient in successful wound repair but persistent in fibrotic pathologies. Understanding fibroblast
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