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Cryoballoon ablation for the treatment of patients with atrial fibrillation (AF) has been utilized in Europe for 15 years. Report patient and procedural characteristics that influence the safety of cryoablation for the treatment of AF. Patients enrolled in the prospective, multicenter Cryo AF Global Registry were treated at 38 European centers. Freedom from a ≥30s episode of AF/atrial flutter (AFL)/atrial tachycardia (AT) at 12-months and serious complications were analyzed. Univariate and multivariable models identified baseline pa