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The more complex reality is that a given condition can be influenced by myriad small-effect noncoding alternatives and/or by rare but serious coding variations, many de novo. Noncoding genomic sequences-for which molecular features cannot generally be inferred-harbor a sizable percentage of these variations, generating an amazing barrier to comprehension higher-order molecular and biological systems of infection. Fortunately, novel genetic technologies-scalable oligonucleotide
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