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 Pulmonary edema is the most common pathophysiological change in pulmonary disease. Aquaporins (AQPs) and Na /K -ATPase play pivotal roles in alveolar fluid clearance. This study aimed to explore the influence of increased alveolar fluid on the absorption of lung fluid.  Eighty New Zealand rabbits were randomly divided into eight groups (  = 10 in each group), and models of different alveolar fluid contents were established by the infusion of different volumes of normal saline (NS) via the endotracheal tube. Five animals in each group were