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BACKGROUND Treatment of hyperglycemia with insulin is associated with increased risk of hypoglycemia in Type 2 Diabetes Mellitus (T2DM) patients receiving total parenteral nutrition (TPN). AIMS To determine the predictors of hypoglycemia in hospitalized T2DM patients receiving total parenteral nutrition (TPN). DESIGN Post-hoc analysis of the INSUPAR study, which is a prospective, open-label, multi-center, clinical trial on adult inpatients with Type 2 Diabetes in a non-critical setting with indication for TPN. RESULTS The study included