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© 2020 International Parkinson and Movement Disorder Society.Pathologic extranodal extension (pENE) impacts therapy planning and is a significant prognostic indicator for patients with mind and neck squamous cell carcinoma (HNSCC). Computed tomography (CT) is a commonly utilized modality for assessment of radiographic ENE (rENE). To determine the predictive worth of CT-identified rENE in predicting pENE, we performed a systematic analysis through a search of 4 databases