https://www.selleckchem.com/pr....oducts/jnj-64619178.
REDD1 suppressed Nrf2 stability by promoting its proteasomal degradation independently of Nrf2's interaction withKelch-like ECH-associated protein 1 (Keap1), but REDD1-mediated Nrf2 degradation required glycogen synthase kinase 3 (GSK3) activity and Ser-351/Ser-356 of Nrf2. Diabetes diminished inhibitory phosphorylation of GSK3β at Ser-9 in the retina of wild-type mice but not in REDD1-deficient mice. Pharmacological inhibition of GSK3 enhanced Nrf2 activity and prevented oxidative stress in the retina of diabetic mice. The finding
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