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of 111 yielded superior synergistic effects. Interestingly, the presence of BDMC and DMC are essential for synergistic effect. Glycoproteomics and proteomics demonstrated that different curcuminoids regulate various protein pathways, such as ribosome, glycolysis/gluconeogenesis, biosynthesis of amino acids, and combination of CUR+DMC+BDMC showed the most powerful effects on down-regulation of protein expression. Our analytical approach provides a systematic understanding of the holistic activity and integration effects of the anti-canc