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Neuroanatomical models of panic disorder (PD) implicate neural activity within an "extended fear network" of brain structures in the physiological symptomology leading up to a panic attack (PA). Here, a voluntary breath-holding paradigm was used to compare brain activity during induction of a hypercapnia state. Blood oxygen level-dependent (BOLD) response was compared between 21 PD individuals and 21 low anxiety matched controls at the peak (12-18 s) of a series of breath-holds. In comparison to the resting condition, BOLD activation a
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