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We have also reviewed our progress in the development of collagen-targeted protein MRI contrast agent with significant improvement in relaxivity and metal binding specificity, and their applications in early detection of fibrosis and metastatic cancer. This article is categorized under Diagnostic Tools in vivo Nanodiagnostics and Imaging Biology-Inspired Nanomaterials Peptide-Based Structures Biology-Inspired Nanomaterials Protein and Virus-Based Structures. © 2020 Wiley Periodicals, Inc.A reusable water bottle w