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fects and should include patient-reported outcomes, such as comfort and acceptability. Copyright © 2020 The Cochrane Collaboration. Published by John Wiley Sons, Ltd.INTRODUCTION Higher potency is obtained with chromogenic substrate (CS) methods and one-stage (OS) method with SynthAFax vs silica-based OS methods on analysis of albutrepenonacog alpha (rFIX fused with albumin, rFIX-FP). AIM Investigation of the effect of contact activator in search for explanation of discrepancy between methods. METHODS Chromogenic Rox Factor IX me