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Cleft palate (CP) can affect breathing, leading to sleep-disordered breathing (SD. Sleep position can affect SDB, but the optimum sleep position for infants with CP is unknown. We aimed to determine the design of a pragmatic study to investigate the effect of the 2 routinely advised sleep positions in infants with CP on oxygen saturations. A multicentered observational cohort. Four UK-based cleft centers, 2 advising supine- and 2 side-lying sleep positions for infants with CP. Infants with isolated CP born July 1, 2015, and December 31