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30 (1.15, 1.47), the hsCRP-based score was 1.35 (1.19, 1.53), and the hsCRP, C-peptide, and HbA1c-based score was 1.35 (1.19, 1.52). The latter score was associated with non-CIMP tumors (HRQ4vsQ1 1.59; 95% CI 1.17, 2.16) but not CIMP-positive tumors (pheterogeneity=0.04). CONCLUSIONS These results further support hypotheses that systemic biomarkers of metabolic health -inflammation and abnormal glucose homeostasis- mediate part of the relationship between several energy balance-related modifiable factors and CRC risk. IMPACT Results suppor
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